In my humble opinion, based on the games I have played, I have never encountered a more detrimental pawn weakness as the double horizontally isolated backward-fated pawn.
[d]4k3/1p1b2p1/5p1p/1p1p4/3N4/P1P5/1P3PPP/4K3 w - - 0 1
b5 and b7 represent such a pawn. I think its penalty should be huge, do not know how much exactly, but really huge (maybe a full pawn, or at least 0.90-0.95cps). There is nothing creative to do with such a pawn, probably just sacrifice it, so that it does not stand in the way of the own pieces.
Maybe the only pawn that beats it in terms of detrimental qualities is the 'blocked double horizontally isolated backward-fated pawn'
[d]8/1p1b2p1/1k3p1p/1p1p4/1K1N4/P1P5/1P3PPP/8 w - - 0 1
Same diagram, but the unfortunate black b pawns are already even blocked by the white king (but better by a minor piece), so that even sacrificing b5 to attempt doubling enemy pawns becomes impossible. Maybe the penalty is already exactly a full pawn, or, in some cases where the pawn thwarts the friendly pieces activity, even larger than a pawn (might seem like a paradoxical statement, but for some game spans it is not).
And another diagram to highlight the importance of backward pawns.
[d]4k3/1p1b2p1/5p1p/1p1p4/1P1N4/P1P5/5PPP/4K3 w - - 0 1
The position is exactly the same as in the first diagram, the only distinction being that the b5 pawn is now already blocked by b4. With this arrangement, doubleness and isolation for b5 remain, but backward-fatedness suddenly disappears, which, of course, favours black. And indeed, I think the position here is a draw (or a likely draw), while the position on the first diagram should be easily won for white.
Interesting to know what penalty you would assign to b5 in both cases.
What is the biggest pawn weakness in your experience?
Best, Lyudmil