These are sequential read/write speed.
For Syzygy it's meaningfull. Latency (access time), I/O per second only matters.
Compare to ATA interface (DMA), USB is CPU-intensive protocol, so expect more nps dropdown.
Compare random vs sequential dropdown for Intel AHCI SATA vs USB 3.0 interfaces:
Intel RST SATA AHCI Drivers
Samsung 840 SSD 250GB
========================
Sequential Read : 514.179 MB/s
Sequential Write : 260.255 MB/s
Random Read 4KB (QD=1) : 24.252 MB/s [ 5921.0 IOPS]
Random Write 4KB (QD=1) : 45.642 MB/s [ 11143.1 IOPS]
Random Read 4KB (QD=32) : 254.315 MB/s [ 62088.6 IOPS]
Random Write 4KB (QD=32) : 179.794 MB/s [ 43895.1 IOPS]
Seagate USB 3.0 HDD
========================
Sequential Read : 61.168 MB/s
Sequential Write : 55.296 MB/s
Random Read 4KB (QD=1) : 0.362 MB/s [ 88.4 IOPS]
Random Write 4KB (QD=1) : 0.953 MB/s [ 232.6 IOPS]
Random Read 4KB (QD=32) : 0.439 MB/s [ 107.1 IOPS]
Random Write 4KB (QD=32) : 0.970 MB/s [ 236.9 IOPS]
do not compare absolute numbers (HDD's are different), but dropdown factor and IOPS.
For USB 3.0 random read speed (important for Syzygy probing) is 140x times slower than sequential read.
For SATA/AHCI it is only 2x slower.
IOPS are dramatically different: SATA is 580x times faster by IOPS
Another example SDCZ80-016G-X46 SanDisk USB 3.0 stick
random speed is 13x slower than sequential